Deuteronomy 27:22-24
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RSV
22 `Cursed be he who lies with his sister, whether the daughter of his father or the daughter of his mother.' And all the people shall say, `Amen.'
23 `Cursed be he who lies with his mother-in-law.' And all the people shall say, `Amen.'
24 `Cursed be he who slays his neighbor in secret.' And all the people shall say, `Amen.'
Under the Law of Moses, marriage with a sister or half-sister (v. 22) was forbidden and cursed, on a par with murder of a neighbour (v. 24). For this reason primordial incest[1] is a very unlikely understanding of the story of Cain and Abel, arising from an effort to accommodate Literal Reading. See discussion of this and other relevant scriptures at Introducing the Fourth Conversation and links from there.